We must seek to maintain a fine balance between CTL-induced immune protection and pathology in the treatment of SARS–associated coronavirus (SARS-CoV) disease. The HLA-A*0201–SSp-1 tetramers we constructed may be useful for monitoring the fluctuation of SSp-1–specific CD8+ T-cell numbers, and by extrapolation, SARS-specific CD8+ T-cell numbers as a whole, in the peripheral blood of SARS patients during clinical or therapeutic treatments, providing an additional indicator for treatment efficacy and short/long-term prognosis.
Paper Link : https://pubmed.ncbi.nlm.nih.gov/15016646/
MBL Tetramer
|
MHC Tetramer |
TCR Teramer |
|
|
Structure |
MHC/peptide |
TCR (α chain/β chain) |
|
Recognition |
Specific TCR |
Specific MHC/peptide complex |
|
Detection |
Antigen-specific T cells |
・Antigen-specific tumors ・Antigen presenting cells |
|
Application |
・Quantification |
・Quantification |