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Monocytes
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Monocytes
CD14+ monocytes are large agranular myeloid-derived leukocytes with roles in the inflammatory and anti-inflammatory processes of the innate immune response. They can differentiate into macrophages and dendritic cells (DC) responsible for phagocytosis, antigen presentation, and cytokine production.
The M1/M2 subtypes of macrophages are key modulators of cancer tumorigenesis. DC-based anti-tumor vaccines are also being explored for cancer immunotherapies. Monocytes are also used in regenerative medicine applications such as wound healing and tissue repair. Their role in the pathology of autoimmune diseases like lupus are providing insight to develop new treatments.
The M1/M2 subtypes of macrophages are key modulators of cancer tumorigenesis. DC-based anti-tumor vaccines are also being explored for cancer immunotherapies. Monocytes are also used in regenerative medicine applications such as wound healing and tissue repair. Their role in the pathology of autoimmune diseases like lupus are providing insight to develop new treatments.